![]() This study conducted a retrospective case-control study on patients with proximal femoral pathological fractures caused by bone metastases from highly malignant tumors in our hospital from 2014 to 2019. In addition, most of the domestic studies on patients with this type of fracture are descriptive studies of a single technique (such as a certain internal fixation method), and there is a lack of randomized controlled studies grouped by different treatments. However, in China, there are still a large number of patients and their families choose conservative treatment after pathological fracture of the proximal femur caused by metastases of tumor, especially the highly malignant tumors such as lung cancer and breast cancer. At present, a large number of scholars believe that as long as the patient’s life expectancy is not too short (>2 months), surgical measures should be used to improve the quality of life among them, endoparasitic proximal femoral replacement is an important technique. Malignant bone metastases of the lower extremities mostly occur in the hips, especially the proximal femur, which is likely to cause the proximal femur pathological fractures, which are important factors for patients with poor prognosis. ![]() The common metastatic sites are the spine and lower extremities. Local tumor resection and endoparasitic replacement, which can be tolerated by most patients, can effectively reconstruct the limb function of these patients and restore their self-care ability.Īdvanced bone metastases from malignant tumors are very common, especially breast cancer, lung cancer, and gastric cancer. Conclusion: Surgical intervention can benefit patients with pathological fractures of the proximal femur due to metastasis of highly malignant tumors in terms of quality of life and survival. After 2 months of treatment, the average MTST score of survivors in the surgical group was 20.38 ± 0.9 (16 - 26 points). Survival analysis showed that the median survival time and 6-month survival rate after fracture in the surgical group were higher than those in the conservative group (P < 0.05). At 2 months after treatment, the KPS score of the surgical group was higher than that of the conservative group (P < 0.05), and the VAS score of the survivors of the surgical group was lower than that of the conservative group (P < 0.05). Results: There was no significant difference in KPS score and VAS score between the two groups at the time of admission (p > 0.05). Musculoskeletal score (MSTS) was used to evaluate limb function in the surgical group at 2 months after the treatment. Survival analysis was implemented to compare the median survival time and 6-month survival rate of the 2 groups. ![]() Methods: Karnofsky performance status (KPS) and visual analogue score (VAS) were counted at the time of admission and 2 months after the treatments. Objective: To investigate whether different treatment methods have an impact on the quality of life and life span after fracture of patients with proximal femoral pathological fractures caused by advanced metastasis of highly malignant tumors.
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